Abstract
Induction of angiogenesis in the ischemic wound bed is critical for tissue repair. Both hypoxia and hyperoxia have been shown to induce angiogenesis, yet the mechanism whereby these two opposing stimuli can produce the same result remains obscure. A rat aortic ring assay was used to test the hypothesis that angiogenesis is regulated via reactive oxygen species (ROS)-mediated signaling. Methods: Rat aortic sections were embedded in Matrigel, grown in minimal media, and treated with continuous hypoxia (3%), normoxia (14%), or hyperoxia (30%).
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