Abstract
The mitochondrial nicotinamide nucleotide transhydrogenase (NNT) uses the protonmotive force to transfer electrons from NADH to NADP, thereby maintaining the NADP/NADPH pool reduced to protect mitochondria from oxidative damage. In this issue, Nickel et al. (2015) show that NNT also operates in reverse, oxidizing the NADP/NADPH pool, thereby disrupting antioxidant defense.
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