Redox Imbalance Theory of Disease, The Triple Oxidant Sink, and The Antioxidant Lifestyle

Abstract

Over 200,000 papers have been written in the last two decades focused on oxidative stress and disease. Much effort has gone into detailing disease associations with pathophysiologic pathways and mechanisms involved in oxidative stress. Supplements and foods have been studied to prevent or reverse this pervasive problem. While individual behaviors have been found to improve oxidative stress, no significant progress has been made toward a broad strategy to curb this disabler and killer. This article is aimed at providing a plausible oxidative-stress-related theory on disease causation. We then provide a multimodal approach aimed at preventing and mitigating the disease-causing inflammatory fallout from redox imbalance. Together the hypotheses provide a foundational framework for research to mitigate the effects of oxidative stress.