Abstract
The reactions between some Ni(II) oligopeptides (Gly-His-Lys, (Gly) 4, Asp-Ala-His-Lys, Gly-Gly-His, βAla-His, and serum albumin) and reduced oxygen species have been characterized by spin-trapping experiments using DMPO and Me 2SO. Most of the peptides possessed superoxide dismutase- and catalase-like activities leading to the formation of either oxene [NiO] 2+ or, in the case of βAla-His, hydroxyl radicals. Both these species may affect DNA integrity through distinct mechanisms.
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