Abstract
BackgroundThe aim of this study was to assess the prognostic value of red blood cell distribution width (RDW) in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI).MethodsA retrospective cohort study (CORFCHD-PCI, [Identifier: ChiCTR-INR-16010153]) of 6050 patients who were hospitalized with a diagnosis of coronary artery disease (CAD) and treated with PCI from January 2008 to December 2016 were enrolled in the study. The primary outcome was long-term mortality after PCI. Clinical follow-up data of participating patients were obtained during an outpatient examination 35.9 ± 22.6 months after PCI. Demographic and clinical data and admission laboratory parameters were recorded, and patients were categorized into two groups according to RDW level (high group ≥13.1%; low group < 13.1%).ResultsMultivariate Cox regression analysis revealed RDW as an independent prognosis factor for cardiac death. The incidence of cardiac death increased 1.33 times in patients in the high RDW group (HR, 1.331; 95% CI, 1.009–1.755, P = 0.043). Kaplan–Meier survival analysis suggested that patients with high RDW tended to have an increased accumulated risk of cardiac death. However, we did not found significant differences in the incidence of long-term mortality (adjusted HR = 1.203[0.941–1.537], P = 0.140), MACCE (adjusted HR = 1.128[0.979–1.301], P = 0.096), MACE (adjusted HR = 1.155[0.994–1.341], P = 0.059), stroke, bleeding events or readmission between the two groups.ConclusionThe baseline level of RDW is an independent predictor for cardiac death in post-PCI CAD patients.
Highlights
Coronary artery disease (CAD) is a complicated multifactor disease
Design and study population The Clinical Outcomes and Risk Factors of Patients with Coronary Heart Disease after percutaneous coronary intervention (PCI) (CORFCHD-PCI) study is a large, single-center retrospective cohort study based on case records and a follow-up registry performed in the First Affiliated
Participants with higher red blood cell distribution width (RDW) values were more likely to be older with a higher hypertension incidence, higher heart ratio (HR), systolic blood pressure (SBP), blood urea nitrogen (BUN), and creatinine (Cr) and lower use of statins and aspirin (P < 0.05)
Summary
Coronary artery disease (CAD) is a complicated multifactor disease. A large number of recent clinical and basic research found that patients with CAD exhibit the traditional risk factors and some newly identified risk factors, such as new lipid parameters, atherogenic index of plasma, nonhigh-density lipoprotein cholesterol and the apolipoprotein B to apolipoprotein A1 ratio [1,2,3]. Peripheral blood parameters were identified, such as platelet distribution width, mean platelet volume, hemoglobin and Biomarkers have become integral to the care of patients with CAD, and sometimes these markers are the key to establishing a diagnosis, determining risk, and guiding therapy. As one of the characteristic parameters of blood, red blood cell distribution width (RDW) was only used for the diagnosis and differential diagnosis of anemia before 2007. A growing number of research gradually found that RDW was closely related to the prognosis of cardiovascular disease. The aim of this study was to assess the prognostic value of red blood cell distribution width (RDW) in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
