Abstract 8625: Impact of Red Blood Cell Distribution Width on Mortality in Diabetic Patients After Percutaneous Coronary Intervention

Abstract

Background: A high red blood cell distribution width (RDW) has been identified as a novel prognostic marker in patients with heart failure. RDW, a measurement of the variability in size of circulating erythrocytes, is obtained routinely by standard blood cell count and used in the differential diagnosis of anemia. But little is known about correlates of RDW with long-term outcomes in diabetic patients with coronary artery disease (CAD). Therefore, we investigated that RDW would be predictive value of prognosis in diabetic patients with CAD treated with percutaneous coronary intervention (PCI). Method and Results: Five hundred ninety-two patients (mean age 66.5±9.0 years, male 80%) with stable CAD who underwent elective PCI were enrolled and followed up for a mean of 4.2 years. Primary endpoint was all cause mortality. Patients were divided into two groups as high or low RDW according to the mean baseline RDW (13.3%). Patients with higher RDW values were significantly older and lower ejection fraction and hemoglobin level. Patients with high RDW (mean 14.0 ± 1.2%) had higher mortality than those with low RDW (mean 12.6 ± 0.3%); (Kaplan Meier, log-rank p=0.01). After adjustment for baseline characteristics using multivariate Cox regression analysis high RDW was an independent predictor of death with a HR of 2.40 (95%CI 1.13-5.31, p=0.02) after adjustment of age, gender, ejection fraction, hemoglobin and serum creatinine. Conclusion: High RDW levels strongly associated with increased risk for long term mortality in diabetic patients undergoing coronary intervension.