Recurrent Extranodal Marginal Zone B-Cell Lymphoma Presenting as a Huge Cheek Mass after Radiotherapy on Ocular Adnexal Lymphoma

Abstract

Extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), also known as MALT lymphoma, is a distinctive group of B-cell lymphomas specified in the World Health Organization classification. The most common anatomic site of origin of MALT lymphoma is the stomach. Other common sites include the skin, salivary glands, ocular adnexa, intestines, and lung. However, it is known that virtually any extranodal anatomic site in the body can be involved by MALT lymphoma. Because patient with MALT lymphoma exhibits an indolent natural history and a favorable prognosis, treatments like excision or radiotherapy or antibiotics should be chosen carefully. Results from radiotheraphy series have demonstrated relatively good local controls with a prolonged clinical course in patients with ocular adnexal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (ocular MALT lymphoma). We report a case of recurrent extranodal marginal zone Bcell lymphoma that presented in the unusual location of the cheek after initial treatment with radiotherapy in ocular MALT lymphoma. To our knowledge, this presentation has not previously been reported in the literature.