Abstract
Key teaching points •We report a case of a 6-year-old African American boy with X-linked CGD who developed DLE–like skin lesions after starting voriconazole. •Voriconazole is commonly used to treat fungal infections in patients with CGD. •Lupus erythematosus–like skin lesions have been reported in carriers of X-linked CGD and, less commonly, in patients with CGD. •Voriconazole is a significant cause of drug-induced photosensitivity, and may play a role in unmasking an underlying predisposition to lupuslike skin lesions. •Photoprotective measures and routine examinations to monitor for skin toxicity, including skin cancer, are prudent during voriconazole treatment.
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