Recurrence of a Familial Giant Multilocular Cardiac Myxoma in a Patient With Carney's Complex

Abstract

A 20-year-old woman, whose father had a past medical history of Carney complex (cardiac myxoma and spotty pigmentation of the skin), was referred to our hospital with a necrotic fingertip. Vital signs and physical examination revealed no additional pathological findings. Blood count showed a slight anemia with a hemoglobin of 11.5 g/dL (reference range 12 to 18 g/dL), and the serum level of C-reactive protein was 57 mg/L (reference range 0 to 5 mg/L). 2D and 3D echocardiography revealed a giant left-ventricular tumor originating from the posterior papillary muscle and posterior wall, prolapsing into the left ventricular outflow tract during systole. A second tumor in the left atrium originating from the mitral valve with diastolic prolapse into the left ventricle could be diagnosed (Figure 1, see also Movies 1–3). The patient underwent immediate surgery. As a result of infiltrating tumor growth, a part of the papillary muscle and some chordae had to be resected. The mitral valve was reconstructed using artificial chordae and ring annuloplasty. Histological findings confirmed a diagnosis of cardiac myxoma (Figure 2). In a 1-year follow-up, the patient was free of symptoms, and echocardiography did not show any signs of …