Abstract

Abstract We have successfully achieved efficient recognition of mismatched sites in double-stranded DNA (dsDNA) through the formation of an invasion complex by using partially non-complementary peptide nucleic acids (PNAs). Owing to mismatches between two PNAs used for invasion, the undesired PNA/PNA duplex, which inhibits invasion complex formation, was destabilized. This approach overcame an inherent challenge in PNA invasion, in particular, undesired PNA/PNA duplex formation resulting from PNA complementarity, thereby enhancing overall invasion efficiency.

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