Abstract
In this study utilizing isotopic techniques for measuring specific corticoids, the oral administration of 8–16 g of NaCl daily for 6–10 days in addition to a constant dietary intake resulted in an increased rate of urinary cortisol excretion in each of 6 subjects. There were rises in the cortisol secretion rates measured in 2 of the subjects, although these were proportionately less than the corresponding increases in cortisol excretion. Although these results seemingly conflict with earlier reports that cortisol production is unresponsive to changes in salt balance, the apparent contradiction is explained by the inability to detect subtle fluctuations with the corticoid measurements previously employed, whereas the methods utilized in this study afford much greater sensitivity. The anticipated lowering of the aldosterone excretion rate occurred as a result of the increased salt intake and the pattern of the aldosterone response was virtually the reciprocal of that of cortisol. Urinary corticosterone, pre...
Published Version
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