Abstract
We have previously proposed that the reciprocal hindlimb scratching (RHS) of mice elicited by intrathecal injection of muscarinic agents is mediated by M 1 muscarinic receptors. In this study, benzhexol potently inhibited pilocarpine-induced RHS (ID 50 = 0.5 ng), methoctramine did not fully block RSH and RS 86 neither produced nor blocked RHS. These data (1) differentiate the three muscarinic agents using this in vivo endpoint, (2) substantiate binding studies characterizing benzhexol and methoctramine as putative M 2 and M 2 antagonists, respectively, and (3) further support using RHS for studying muscarinic agents.
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