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Drug Development ResearchVolume 40, Issue 2 p. 101-103 IntroductionFree Access Challenges and opportunities for developing muscarinic receptor subtype-based therapeutic agents James C. Blosser, Corresponding Author James C. Blosser Astra Arcus U.S.A., Rochester, New YorkAstra Arcus U.S.A., Rochester, New YorkSearch for more papers by this authorJohn E. Macor, John E. Macor Astra Arcus U.S.A., Rochester, New YorkSearch for more papers by this authorWilliam S. Messer Jr., William S. Messer Jr. Department of Medicinal and Biological Chemistry, University of Toledo, Toledo, OhioSearch for more papers by this author James C. Blosser, Corresponding Author James C. Blosser Astra Arcus U.S.A., Rochester, New YorkAstra Arcus U.S.A., Rochester, New YorkSearch for more papers by this authorJohn E. Macor, John E. Macor Astra Arcus U.S.A., Rochester, New YorkSearch for more papers by this authorWilliam S. Messer Jr., William S. Messer Jr. Department of Medicinal and Biological Chemistry, University of Toledo, Toledo, OhioSearch for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1098-2299(199702)40:2<101::AID-DDR1>3.0.CO;2-PCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References Allard WJ, Sigal IS, Dixon RA (1987): Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor. Nucleic Acids Res 15: 10604. 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Ward JS, Merritt L, Klimlowski VJ, Lamb ML, Mitch CH, Bymaster FP, Sawyer B, Shannon HE, Olesen PH, Honore T (1992): Novel functional M1 selective muscarinic agonists. II. Synthesis and structure-activity relationships of 3-(pyrazinyl)-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore. J Med Chem 35: 4011– 4019. Wess J, Bonner TI, Dorje G, Brann MR (1990): Delineation of muscarinic receptor domains conferring selectivity of coupling to guanine nucleotide-binding proteins and second messengers. Mol Pharmacol 38: 517– 523. Wess J, Maggio R, Palmer JR, Vogel Z (1992): Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation: A study with m3 muscarinic receptor point mutants. J Biol Chem 267: 19313– 19319. Citing Literature Volume40, Issue2February 1997Pages 101-103 ReferencesRelatedInformation

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