Abstract
Reciprocal communication between L-type Ca2+ channel and ryanodine receptor in frog skeletal muscle
Highlights
9 Mark Hibbert & Brian Jewell – Myofilament Casensitivity increases with sarcomere length Myofilament sensitivity to [Ca2+] is not a unique relationship: this paper provided unequivocal evidence that it is length-dependent, augmenting that due to myofilament overlap as revealed in s.l.-tension relationship
Conventional views assume that the increased force that is required to prevent collapse is produced by stretching the active muscles
In opposition to this view we propose that the force is associated with active shortening of the muscles
Summary
The Society returns to Guy’s Campus for a joint meeting with the Chilean Physiological Society. The research groups of Richard Siow and Giovanni Mann (Chair of the Society’s Executive Committee) are collaborating in a study of the effects of reactive oxygen species on signal transduction in cultured vascular endothelial and smooth muscle cells, with particular emphasis on the role of transcription factors involved in transactivation of antioxidant stress genes. Nnaemeka Amobi and Christopher Smith continue their studies on the basic physiology and pharmacology of human vas deferens - and give their thanks to all of you who have had vasectomies Their aim is to understand how the contractile properties of the circular and longitudinal muscle contribute to the propulsive function that ensures efficient sperm transport and emission. Malcolm Irving’s group is focused on molecular mechanisms in muscle contraction and its regulation They use X-ray and fluorescence methods to measure conformational changes of myosin and troponin in their native environment in isolated muscle cells. It manages air quality networks on behalf of DEFRA and local authorities throughout SE England, providing services such as site management, quality assurance, local site operator support and reporting including the dissemination of measurements via the Internet
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