Abstract
Receptors for histamine, acetylcholine and gastrin were evidenced in isolated cells from gastric mucosa. Secretory activities measured by aminopyrine accumulation and gastrin binding have been studied in two cell preparations: rat gastric mucosal cells isolated with pronase (P-cells) and rabbit gastric mucosal cells isolated with collagenase (C-cells). C-cells showed higher secretory responses than P-cells to histamine and acetylcholine stimulations but gastrin did not stimulate the two cell preparations. Gastrin binding was higher for P-cells than for C-cells. These results suggest an alteration of the histamine receptor by pronase but not of gastrin receptor. Gastrin binding seems to be unrelated to acid secretory response measured by aminopyrine accumulation.
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