Abstract
Publisher Summary This chapter discusses the receptors that mediate the facilitatory actions of histamine (HA) on prolactin (PRL) and luteinizing hormone (LH) release in rats. One of the questions regarding the effects of histamine agonists and antagonists is whether HA-induced responses involve specific receptors. The presence in rat brain of two types H1 and H2-specific receptor sites for HA has been recently documented. H2 receptors are involved in the facilitatory effect of HA on PRL release in male rats. The actions of histamine involve specific receptors that by means of the use of specific agonists and antagonists have been tentatively characterized. An aspect to be remarked is the involvement of H2 receptors in the PRL stimulatory action of HA in male rats and the assumed role of H1 receptors in the PRL and LH release found in ovariectomized, steroid-treated rats. These results suggest that ovarian steroids are critically important in the expression of the neuroendocrine responses to histamine.
Published Version
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