Abstract
This chapter discusses the possible role of receptors for C3 on B lymphocytes in the immune response. Complement–receptor lymphocytes (CRLs) have been defined as a population of lymphoid cells found in many mammalian species, including man, which is capable of binding antigen–antibody–complement complexes through a membrane receptor for a modified complement component (C3). CRL can be readily identified and isolated by virtue of their ability to form rosettes with sheep erythrocytes that have been sensitized with rabbit antibody against the Forssmann antigen and complement. CRL have a characteristic distribution in lymphoid organs thatgrossly coincides with that of lymphocytes carrying easily detectable immunoglobulin (Ig) determinants on their membranes. They are absent from the thymus and can be found in large numbers among cells from the lymph nodes, spleen, and thoracic duct lymph of normal mice. The chapter discusses the differences between CRL and mononuclear phagocytes. It also describes the function of the C3 receptor on lymphocytes.
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