Abstract
Metal–organic frameworks (MOFs), as a new class of porous solid materials, have emerged and their study has established itself very quickly into a productive research field. This short review recaps the recent advancement of chiral MOFs. Here, we present simple, well-ordered instances to classify the mode of synthesis of chiral MOFs, and later demonstrate the potential applications of chiral MOFs in heterogeneous asymmetric catalysis and enantioselective separation. The asymmetric catalysis sections are subdivided based on the types of reactions that have been successfully carried out recently by chiral MOFs. In the part on enantioselective separation, we present the potentiality of chiral MOFs as a stationary phase for high-performance liquid chromatography (HPLC) and high-resolution gas chromatography (GC) by considering fruitful examples from current research work. We anticipate that this review will provide interest to researchers to design new homochiral MOFs with even greater complexity and effort to execute their potential functions in several fields, such as asymmetric catalysis, enantiomer separation, and chiral recognition.
Highlights
Metal–organic frameworks (MOFs), as a unique class of coordination polymers, exist as well-organized crystalline structures and exhibit varied coordination geometries [1,2,3,4]
A hexane-isopropyl alcohol (96:4, v/v) system was used as a mobile phase, which afforded a prominent baseline resolution for the separation of both pairs of the Hailili et al [111] studied the enantioselective separation of the chiral compounds (±)-ibuprofen and (±)-1-phenyl-1,2-ethanediol by the chiral MOF (Me2 NH2 )2 [Mn4 O(D-cam)4 ]·5H2 O (46), which acted as a stationary phase in high-performance liquid chromatography (HPLC)
This review summarizes the present progress of the synthesis of chiral MOFs and their applications as catalysts in asymmetric reactions and chiral stationary phase in the enantioselective separation of chiral molecules
Summary
Metal–organic frameworks (MOFs), as a unique class of coordination polymers, exist as well-organized crystalline structures and exhibit varied coordination geometries [1,2,3,4]. One of the most actively emerging fields is the design and synthesis of chiral MOFs [24] and exploring their applications in various fruitful research fields, including asymmetric catalysis [25,26,27,28], molecular recognition [29], non-linear optics [30,31,32], and enantioselective separation [33,34]. The main advantages of chiral MOFs over other chiral stationary phases are their well-ordered frameworks containing available chiral pores to interact with guests and their controllable functionalities by varying chiral linkers and metal ions as the separation isomers require.
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