Recent Developments of Palladium- and Rhodium-Catalyzed β-Carbon Elimination Strategies

Abstract

AbstractThe activation of C–C bonds via transition metal catalysis has become an increasingly popular strategy in organic synthesis. An emerging method to cleave C–C bonds is to facilitate a β-carbon elimination using rhodium or palladium catalysis. This elementary step typically relies on a thermodynamic driving force, such as the relief of ring strain or steric strain. More recently, the use of neopentyl metal species or chelation assistance has enabled this difficult transformation. This review will cover recent synthetic applications of β-carbon eliminations under palladium and rhodium catalysis.1 Introduction2 Chelation-Assisted β-Carbon Elimination Reactions3 β-Carbon Elimination from Neopentyl–Pd Species4 Pd-Catalyzed Catellani Reactions5 β-Carbon Elimination Reactions of Cyclopropanes6 Conclusion