Abstract
Tissue engineering is a promising strategy for the repair and regeneration of damaged tissues or organs. Biomaterials are one of the most important components in tissue engineering. Recently, magnetic hydrogels, which are fabricated using iron oxide-based particles and different types of hydrogel matrices, are becoming more and more attractive in biomedical applications by taking advantage of their biocompatibility, controlled architectures, and smart response to magnetic field remotely. In this literature review, the aim is to summarize the current development of magnetically sensitive smart hydrogels in tissue engineering, which is of great importance but has not yet been comprehensively viewed.
Highlights
Tissue engineering, a branch of regenerative medicine, refers to the application of supporting cells, material scaffolds, bioactive molecules, or their combinations to repair and reconstruct tissues and organs
We aim to summarize the preparation methods and current development of magnetically sensitive smart hydrogels in tissue engineering, especially in bone, cartilage, and neural tissue engineering, which are of great importance but have not yet been comprehensively reviewed
The results suggested that magnetically actuated cellladen hydrogels demonstrated more mineralization and faster vascularization in comparison with magnetic nanoparticles (MNPs) or static magnetic field (SMF) alone
Summary
A branch of regenerative medicine, refers to the application of supporting cells, material scaffolds, bioactive molecules, or their combinations to repair and reconstruct tissues and organs. Hydrogels have been shown to be one of the most applicable biomaterials in tissue engineering (Kabu et al, 2015; Madl et al, 2017, 2019; Deng et al, 2019) mainly attributed to their inner 3D network microstructures, moderate biocompatibility, and good water content feature, which are analogous with those of the natural tissue (Cui Z.K. et al, 2019; Zhu et al, 2019). Considering the above advantages, hydrogels have been conducted into the biomedical application to provide a tunable three-dimensional scaffold for cell adhesion, migration, and/or differentiation, and they could be designed as the platform for the controlled release of cytokines and drugs in tissue engineering and drug delivery (Huang et al, 2017; Jiang et al, 2017; Hsu et al, 2019; Wei et al, 2019; Zheng et al, 2019).
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