Abstract
AbstractThis review article summarizes recent developments and innovations in China's pharmaceutical process chemistry over the last several decades. Case studies of dozens of blockbuster drug processes are presented, including bulk drugs, such as the over-the-counter medicine biotin, demonstrating China's substantial effort to green its pharmaceutical processes. Owing to the increasing stringent environmental regulations, Chinese chemists have invented several cutting-edge and eco-friendly synthetic methods that are beneficial to environmental protection. Applied to large-scale industrial production, these processes have a greatly reduced environmental footprint, promoting the sustainable development of global economy and health.
Highlights
With the rapid improvement in China’s modern industry and the Chinese people’s standard of living over the past decades, China has become a major player in pharmaceutical production
China is a country experiencing a rapid increase in its aging population, which has coincided with the massive consumption of medicine
According to recent statistics,[1] in 2017, there were more than 2,000 pharmaceutical companies in China producing active pharmaceutical ingredients (APIs)
Summary
With the rapid improvement in China’s modern industry and the Chinese people’s standard of living over the past decades, China has become a major player in pharmaceutical production. E38 Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China Tang et al Scheme 18 Synthesis of chiral bicyclic imidazole catalyst R-DPI and related R-PDPI derivative.
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