Abstract
The construction of a C-S bond is a powerful strategy for the synthesis of sulfur containing compounds including sulfides, sulfoxides, and sulfones. Recent methodological developments have revealed lots of novel protocols for C-S bond formation, providing easy access to sulfur containing compounds. Unlike traditional Ullmann typed C-S coupling reaction, the recently developed reactions frequently use non-halide compounds, such as diazo compounds and simple arenes/alkanes instead of aryl halides as substrates. On the other hand, novel C-S coupling reaction pathways involving thiyl radicals have emerged as an important strategy to construct C-S bonds. In this review, we focus on the recent advances on the synthesis of sulfides, sulfoxides, and sulfones from non-halide substrates involving C-S bond construction.
Highlights
Sulfur containing compounds are a fundamental building block in organic synthesis [1,2].They are of great significance in bioactive natural products, pharmaceutical drugs, pesticides, and materials [3,4,5,6,7,8]
The traditional Ullmann typed reaction, which has been well established in the past several decades, has provided lots of synthetic protocols for diaryl sulfides and aryl alkyl sulfides through transition-metal catalyzed C-S coupling reaction of aryl halides with aryl thiols or other sulfur precursors [9,10,11]
The research on the synthetic methods for organosulfur compounds is of great importance in both academic research and industry
Summary
Sulfur containing compounds are a fundamental building block in organic synthesis [1,2]. They are of great significance in bioactive natural products, pharmaceutical drugs, pesticides, and materials [3,4,5,6,7,8]. Sulfur containing compounds, such as sulfides, sulfoxides, and sulfones, constitute a large portion of pharmaceutical drugs possessing a variety of biological activities. The construction of C-S bond is considered as an efficient strategy for the synthesis of sulfur containing compounds. We highlight the very recent advances in novel strategies that take advantage of C-S bond construction for the synthesis of sulfides, sulfoxides, and sulfones from non-halide substrates.
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