Abstract
Type Ⅰ interferon (IFN-Ⅰ) has a broad-spectrum of antiviral immune protective effects and has been used clinically to treat a variety of viral diseases. When IFN-Ⅰ binds to its specific receptor, it triggers an extremely complex signaling pathway network to produce a large number of antiviral proteins that exert antiviral activity and regulate immunity. During acute viral infections such as highly pathogenic H5N1 avian influenza virus infection, the cytokine storm induced by excessive activation of the IFN-Ⅰ signaling pathway may further worsen the condition. In chronic viral infections such as hepatitis C virus infection, IFN-Ⅰ causes a series of pathological effects while exerting therapeutic effects. Therefore, studies on activating or blocking the IFN-Ⅰ signaling pathway will help guide the rational and efficient use of IFN-Ⅰ in clinical treatment for viral diseases. Key words: Interferon type Ⅰ; Signal transduction; Viral infection; Pathogenic effect
Published Version
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