Abstract
This review reports the progress of the recent development of graphene-based microfluidic sensors. The introduction of microfluidics technology provides an important possibility for the advance of graphene biosensor devices for a broad series of applications including clinical diagnosis, biological detection, health, and environment monitoring. Compared with traditional (optical, electrochemical, and biological) sensing systems, the combination of graphene and microfluidics produces many advantages, such as achieving miniaturization, decreasing the response time and consumption of chemicals, improving the reproducibility and sensitivity of devices. This article reviews the latest research progress of graphene microfluidic sensors in the fields of electrochemistry, optics, and biology. Here, the latest development trends of graphene-based microfluidic sensors as a new generation of detection tools in material preparation, device assembly, and chip materials are summarized. Special emphasis is placed on the working principles and applications of graphene-based microfluidic biosensors, especially in the detection of nucleic acid molecules, protein molecules, and bacterial cells. This article also discusses the challenges and prospects of graphene microfluidic biosensors.
Highlights
The rapid development of Microfluidics Technology in recent years has caused a revolutionary impact in the fields of physics [1,2], materials [3,4], and biomedicine [5,6,7]
Graphene exhibits great application potential in many fields due to its excellent physical and chemical properties, it is worth mentioning that the strong van der Waals (vdW) force between graphene sheets is far greater than the interaction with solvents, making it difficult to dissolve in water and common organic solvents, which limits its wide application in microfluidic platforms
CoInnctlhuissiroenvsieawndaFrtuictluer,ewWeodrikscussed the latest work on graphene and microfluidic technology, focusiIngthoins rmevicierowfluaridtiiccles,ewnseodrsisbcuaseseddotnhegrlatpehstenweonrkanoonmgartaeprhiaelnsefoarndthme dicertoefclutiiodnicotfechhneomloicgayl, focusing on microfluidic sensors based on graphene nanomaterials for the detection of chemical substances and biomolecules
Summary
The rapid development of Microfluidics Technology in recent years has caused a revolutionary impact in the fields of physics [1,2], materials [3,4], and biomedicine [5,6,7]. There have been considerable efforts have been made to combine the sensors with microfluidics to further broaden the applications of sensors [13]. The conclusions of this article are summarized, and the challenges and application prospects of graphene microfluidic sensors are proposed
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