Laser induced fluorescence technology for early detection of diabetes via optical fiber microfluidic sensor

Abstract

This research explores the use of direct write laser technology to reduce manufacturing costs and time by using Polymethyl methacrylate (PMMA) sheet. The process has a maximum channel width of 208 µm for zigzag channels and 205.66 µm for straight channels, limiting droplet miniaturization. Microfluidics technology offers potential for creating graphene, glucose, and rhodamine B biosensor devices for various applications. Combining these materials offers benefits like miniaturization, reduced response time and chemical consumption, and improved device reproducibility and sensitivity. The study also highlights advancements in chip materials, device assembly, and material preparation for graphene-based microfluidic sensors. The findings show that optical fiber microfluidic biosensor devices have higher spectral resolution than traditional fluorescence spectrometers, enabling precise identification of mixture components and fluorescence enhancement analyses.