Abstract
The formulation of poorly soluble drugs is one of the most difficult tasks for pharmaceutical formulators. Conventional techniques for increasing the solubility of these drugs have had limited success. This is especially true when dealing with drugs that have low aqueous and organic solubility. Solubility is an important determinant of drug liberation and thus drug absorption, and it plays an important role in formulation oral bioavailability. A drug solubility directly influences its dissolution rate. Most New drugs have low water solubility, making them difficult to formulate into drug delivery systems. As a result, improving the solubility of poorly water soluble drugs is one of the necessary preformulation steps in pharmaceutical product development research. The use of nanoparticles in the formulation of hydrophobic drugs improves their solubility and efficacy. Emulsion-solvent evaporation method, Double Emulsion and Evaporation method, Salting out method, Emulsions diffusion method, Antisolvent Precipitation Method, Polymerization method, and Coacervation or Ionic Gelation method can all be used to make nanoparticles. Bottom-up methods such as Antisolvent precipitation are the most efficient and cost effective in the preparation of nanoparticles.
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