Abstract
Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in Dalbergia and Vaccinium spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized. This review focuses on the effects of pterostilbene on certain diseases to explore its targets, explain the possible mechanism, and look for potential therapeutic applications.
Highlights
Pterostilbene (3,5-dimethoxy-40 -hydroxy-trans-stilbene) is a trans stilbene compound with bioactivity
Pterostilbene had a strong bacteriostatic effect on Fusobacterium nucleatum, a key periodontal pathogen, and the minimum inhibitory concentration was more than 60 times lower than that of resveratrol; pterostilbene’s antibacterial activity mechanism involved inducing the leakage of cell contents, which resulted in the loss of bacterial cell vitality [95]
Besides extraction from natural products, pterostilbene can be obtained by biosynthesis and chemical synthesis
Summary
Pterostilbene (3,5-dimethoxy-40 -hydroxy-trans-stilbene) is a trans stilbene compound with bioactivity. Indian herbal medicine, was studied by high performance liquid chromatography These phenolic compounds are known antioxidants and are used in cancer chemoprophylaxis. They can reduce mortality from coronary heart disease by increasing high-density lipoprotein content and inhibiting platelet aggregation [2]. Considering these findings, resveratrol and pterostilbene have become the focus of research. Resveratrol is a popular molecule that has been widely studied in recent years, and it is one of the main components of the extract of Dragon’s blood. Resveratrol and pterostilbene have similar structures, and pterostilbene is a main bioactive compound in the extract of Dragon’s blood. Pterostilbene is characterized by low molecular weight (Figure 1) and good liposolubility, liposolubility, allowing to cross cross the theblood-brain blood-brainbarrier barrier[16]
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