Abstract

Aspidosperma alkaloids are complex indole-containing natural products that historically have generated a considerable amount of interest from the synthetic community. Many members of this class are biologically active and replete with functional groups and chiral centers which provide a challenging proving ground for new methodology. This review will highlight recent advances in the total synthesis of molecules such as aspidospermidine, the subincanadines, vinblastine, and haplophytine in the past decade.

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