Abstract
Nano particles are arguably used in the biomedical field. Cancer remains a significant public health threat. Gold nanoparticles (AuNPs) are a natural choice for treatment of cancer, due to their simplicity of preparation, their unique optical characteristics, stability, electronic structure, nanostructure, biocompatibility, flexibility in sensing and detection. AuNPs can be conjugated with all the human body’s physiological mechanisms. Various nanomaterials strategies have been approached to increase tumor selectivity, therapeutic index, and anticancer activity, as the standard drug delivery method lacks proper distribution of chemotherapeutics given the complexity of the cancer cells. Recent studies have revealed that AuNPs can readily be modified to allow direct pharmaceutical drug delivery to the target tissue. AuNPs can also deliver their contents in response to external or internal stimuli after approaching their target site. Accordingly, we discussed advanced AuNPs features that showed great potential in improving precision treatments in both non-personalized and high accuracy applications and highlighted the in-depth role of nanotechnology-based medication delivery as well as the most difficult aspect of medicinal effectiveness and safety.
Highlights
The use of Nano science, as a new method in disease detection, management, and treatment, has received increasing attention in the biomedical area[1]
Various nanomaterials strategies have been approached to increase tumor selectivity, therapeutic index, and anticancer activity, as the standard drug delivery method lacks proper distribution of chemotherapeutics given the complexity of the cancer cells
9 CONCLUSION AuNPs demonstrate great potential in cancer therapy and drug delivery, as well as biodiagnostic and imaging. In spite of these advancements, the properties of AuNPs, such as long-term toxicity, stability, and immune response effects, high surface-to-volume ratio, surface versatility, low inherent toxicity, biocompatibility, optical properties, and ability to functionalize with biomolecules to achieve the desired selectivity, deserve further exploration
Summary
The use of Nano science, as a new method in disease detection, management, and treatment, has received increasing attention in the biomedical area[1]. Nanotechnology-based therapeutic agents are being developed as an alternate technique, by modifying the physicochemical properties of antiviral medications to enhance treatment efficiency When it comes to the effectiveness and safety profile of nanotechnologyintegrated nano-medicines, there are still many crucial elements to consider, such as immunogenicity, target selectivity, and biocompatibility. The transport of antisense DNAs to the nucleus for controlling alternative splicing of pre-mRNA of diseaserelated genes is an appealing technique for gene therapy[63,64,65] Such pH-responsive AuNPs coated with layers of binding materials are promising for increased DNA governed by the terms. (acrylic acid) (PAA, -25 to -60 mV), poly (N-(2,3-dihydroxypropyl) acrylamide) (PDHA, slightly negatively charged)
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