Recent Advances in Asymmetric Organomulticatalysis

Abstract

AbstractAsymmetric multi‐catalysis, designed to mimic catalytic processes in nature, is a powerful instrument to fulfil fascinating transformations. As a result, this area of research has attracted considerable interests within chemistry communities. Although there are numerous reviews involving multi‐catalysis, reviews describing asymmetric organomulticatalysis remain rare. Taking into consideration that organocatalysts possess the superiorities of effortless availability, inexpensiveness, hypotoxicity, facile handling and hyposensitivity to moisture and oxygen, they have definite advantage in their own distinct modes of activation when utilized in multi‐catalytic reactions. Organomulticatalysis refers to the synthetic strategies of modular combination of organo‐catalyzed reactions into one synthetic operation with minimum workup or change in conditions. It is apparent that a variety reports utilizing the concept of enantioselective organomulticatalysis have substantially surfaced in the past few years. Hence, it is indispensable to succinctly present all such reports by means of disclosing the mechanistic analysis, as well as the challenges and issues associated in the development of the asymmetric catalytic system. Additionally, this review will introduce some of the unsettled conundrums and possible innovations in this field.magnified image