RECENT ADVANCES IN ANTIMICROBIAL ACTIVITY OF PYRIMIDINES: A REVIEW

Pranali A Jadhav Pranali A Jadhav,Atul Baravkar Atul Baravkar

doi:10.22159/ajpcr.2022.v15i2.43686

Abstract

Over the past era, development of small heterocycles as potential therapeutics has been a zone of major interest. A large number of pyrimidine derivatives are of considerable biological and chemical interest. Pyrimidine derivatives have shown numerous biological activities such as antimicrobial, antitubercular, anticancer, anticonvulsant, antidiabetic, antiviral, and anti-inflammatory. Being a heterocyclic compound, Pyrimidine finds its use for designing synthesis of newer biologically active structures, as its aromaticity makes it relatively stable, also reactive sites which allow for functionalization. Several amino derivatives of nitrogen-containing heterocycles such as pyrimidine, pyridine possess an antimicrobial activity. In this review, recent advancements in the antimicrobial activity of pyrimidine derivatives have been reported.

Highlights

Pyrimidine is the most important six-membered aromatic heterocyclic ring containing two nitrogen atoms
Fig. 3: 1,2,4-triazolo[1,5-a] pyrimidine derivatives synthesized compounds were evaluated for their in vitro antibacterial activity against Escherichia coli (ATCC25922) and Pseudomonas aeruginosa (ATCC27953) as examples of Gram-negative bacteria and Staphylococcus aureus (ATCC29213) and Bacillus subtilis (NRRL-B-4219) as examples of Gram-positive bacteria
The synthesized compounds were screened for their antimicrobial activity against four bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus niger)

Summary

Introduction

Pyrimidine is the most important six-membered aromatic heterocyclic ring containing two nitrogen atoms. Fig. 3: 1,2,4-triazolo[1,5-a] pyrimidine derivatives synthesized compounds were evaluated for their in vitro antibacterial activity against Escherichia coli (ATCC25922) and Pseudomonas aeruginosa (ATCC27953) as examples of Gram-negative bacteria and Staphylococcus aureus (ATCC29213) and Bacillus subtilis (NRRL-B-4219) as examples of Gram-positive bacteria.

Results

Conclusion