Abstract
Reasons of Unknown HPLC Peaks during Hemoglobin Analysis for Patients with Beta Thalassemias
Highlights
Beta-thalassemias (β-thal) are inherited quantitative disorders of haemoglobin (Hb) leading to underproduction of the beta globin chains of hemoglobin
In β-thal, the synthesis of normal α globin chains from the unaffected α globin gene continues as normal, resulting in the accumulation within the erythroid precursors of excess free α globin chains, which precipitate in the red cell precursors in the bone marrow forming inclusion bodies
The major problem in β-thal is accumulation of excess free globin chains (α-Hb) in the erythrocytes precursors in the bone marrow and peripheral erythrocytes forming inclusion bodies, patients with β0 thalassemia is clinically worse than patients with β+ thalassemia, and there is a general trend in this direction [5,6]
Summary
Beta-thalassemias (β-thal) are inherited quantitative disorders of haemoglobin (Hb) leading to underproduction of the beta globin chains of hemoglobin. University Sultan Zainal Abidin (UniSZA), Faculty of Medicine and Health Sciences, Kuala Terengganu, Malaysia
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