Real-World Avoidance of Glucose Excursions with the Guardian Connect CGM System’s Predictive Alerts

Abstract

The Medtronic GuardianTM Connect continuous glucose monitoring (CGM) system, with predictive high and low glucose alerts, allows users to view sensor glucose (SG) data on a smartphone that notifies them 10-60 minutes before an excursion. The rates of alerts and outcomes of users on the GuardianTM Connect system were evaluated. We identified 2,541 users with >5 days of SG data in the CareLinkTM database from Jan 2, 2017-Sep 5, 2017 (data collected Jan 2, 2017-Dec 14, 2017). Excursions were identified when SG values were beyond the users’ preset SG threshold limit for ≥15 min. As a control, alerts were simulated during user alert-disabled periods to compare excursion frequency. Excursion durations following the alert times were segmented into avoided, ≤20min, 20-60 min, and >60min. Simulated SG limits were 202mg/dL (11.2mmol/L) for high and 70mg/dL (3.9mmol/L) for low. Simulated predictive times before excursions were 12.5min for high and 17.5min for low. The Table shows percentages of each alert resulting in an excursion. Users who enabled predictive alerts avoided 60% of low and 39% of high events. The percentage point improvement for excursions avoided was 28% and 31% following predicted low and high alerts vs. control. Stand alone CGM technology, like the GuardianTM Connect system, with predictive alerts are useful for tracking SG and enabling timely actions that help avoid high and low excursions. Disclosure O. Cohen: Employee; Self; Medtronic. S. Abraham: None. C.M. McMahon: Employee; Self; Medtronic MiniMed, Inc.. P. Agrawal: None. R. Vigersky: Employee; Self; Medtronic MiniMed, Inc..