Abstract
Rheumatoid arthritis and osteoarthritis can be treated through specific drug injection into the intra-articular space. Several failures during drug injection attempts with conventional fluoroscopy and ultrasonography in a small area of the intra-articular space have been reported. In this work we present an innovative impedance measurement-based method/algorithm for needle tip positioning to enhance image-guided intra-articular vaccination treatment. A novel algorithm for detecting the intra-articular space in the elbow and knee joints of a live porcine model is reported. An impedance measurement system was developed for biological tissue measurement. The electrical impedance in the intra-articular space was monitored and the needle tip was examined by ultrasonography. The contrast dye was vaccinated and checked using fluoroscopy to confirm that the dye was properly inoculated in the cavity. The electrical impedance was estimated for various needle inclusion profundity levels in saline solution, which were broadly used to evaluate the proposed device for in vivo examinations. Good efficiency was observed in the impedance-based measurements using a monopolar injection needle for intra-articular therapy. To enhance the needle tip positioning for intra-articular therapy, the intended impedance measurement device with a monopolar injection needle can be used as a complement to existing modalities.
Highlights
Cartilage deterioration is a typical pathological occurrence in different kinds of arthritis, such as osteoarthritis (OA) and rheumatoid arthritis (RA), and is a significant cause of joint dysfunction accompanied by “quality of life” disability in patients [1]
A discrete Fourier transform (DFT)-based impedance analyzer with a monopolar injection needle was developed to track the position of the tip of the needle, and its usefulness was evaluated in porcine tissue
The electrical impedance of electrode configuration wherein the monopolar injection needle was used as the working electrode, the saline solution was measured using the fabricated AD5933-based impedance analyzer, with a and Ag/AgCl was used as the pseudo-reference electrode/counter electrode in the frequency range two-electrode configuration wherein the monopolar injection needle was used as the working electrode, of 10 Hz−100 kHz
Summary
Cartilage deterioration is a typical pathological occurrence in different kinds of arthritis, such as osteoarthritis (OA) and rheumatoid arthritis (RA), and is a significant cause of joint dysfunction accompanied by “quality of life” disability in patients [1]. A discrete Fourier transform (DFT)-based impedance analyzer with a monopolar injection needle was developed to track the position of the tip of the needle, and its usefulness was evaluated in porcine tissue. A novel algorithm was developed to detect the needle tip in the intra-articular space using EIS with a monopolar injection needle and drug injection in the articular cavity. Based on the available literature and to the best of our knowledge, the present case study is the first report of an impedance measurement system with a monopolar needle for drug injection into the intra-articular space of an animal model. The results demonstrate the effectiveness of the developed algorithm in detecting the intra-articular space using a monopolar needle-based impedance measurement system
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