Abstract
Ultrasonography or fluoroscopy-guided needle injection has been used for intra-articular injection therapy against adhesive capsulitis and joint diseases. To improve the image-guided intra-articular injection therapy, electrical impedance measurement based positioning of the needle tip in the target tissue can be applied. The feasibility of the discrimination for the tissue layer at which the disposable monopolar injection needle tip position was investigated using the discrete Fourier transform (DFT)-based impedance measurement system and the ultrasound imaging device. The electrical impedance spectra of the pork tissue measured in the frequency range of 200 Hz to 50 kHz were characterized by designed equivalent circuit modeling analysis. The normalized impedance data of the tissue layers (dermis, hypodermis, and muscle) were significantly different from each other (p-value < 0.001). The DFT-based impedance measurement system with a monopolar injection needle can be complementary to the image-guided intra-articular injection therapy.
Highlights
Intra-articular injection therapy is used for the treatment of adhesive capsulitis [1] and joint diseases, including rheumatoid arthritis and osteoarthritis [2]
ADuCM350 mainly consists of a 16 MHz ARM CORTEX M3 processor and analog front end specially designed for high precision data acquisition with digital to analog converter (DAC) and analog to digital converter (ADC)
The discrete Fourier transform (DFT)-based impedance measurement system was controlled through serial communication by a LabVIEW based graphical user interface (GUI)
Summary
Intra-articular injection therapy is used for the treatment of adhesive capsulitis [1] and joint diseases, including rheumatoid arthritis and osteoarthritis [2]. Due to the limitations of imaging-guided injections described above, the development of complementary methods for precise needle positioning and effective drug administration in the pathological tissues is still required. Since the electrical properties (conductivity, dielectric constant) of porcine tissues are similar to those of human counterparts [18], the pork tissue was used for the impedance measurement using the monopolar injection needle. While positioning the tip of the monopolar injection needle in the specific tissue layer with the aid of ultrasonography, the electrical impedance data of the tissue layers were monitored. The experimental result showed the feasibility of the developed DFT-based impedance measurement system for real-time monitoring of the tip position of the monopolar injection needle in the tissues
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