Abstract
Microbubbles (MBs), generally of 1 − 4 µm diameter, are useful in contrast ultrasound imaging. MBs can also be used as a therapeutic agent for sonothrombolysis when combined with ultrasound and thrombolytic drugs. Recently, large MBs (10−20 µm diameter) produced by flow focusing microfluidic devices (FFMDs) have been demonstrated to exhibit enhanced bioeffects for sonothrombolysis applications. However, one remaining problem that limits the adoption of this technology is the lack of dynamic monitoring and control of MB diameter. In this study, we demonstrate the regulation of MB diameter in real-time by the incorporation of proportional-integral (PI) feedback control system into an FFMD with an integrated micro Coulter particle counter. With this controller, MB diameters were produced between 14 and 24 µm.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
