Abstract
Background: The reduction of pharmacological treatment after allergen immunotherapy (AIT)forhouse dust mites (HDMs) has been little studied in children. Objective: To evaluate the reduction of pharmacological treatment comparing children that receive HDM immunotherapy (AIT group) versus only pharmacotherapy. Methods: Ahistoric cohort of children with rhinitis or asthma was assessed. The main outcome was the frequency of complete drug discontinuation. Results: 100%drug reduction was higher for rhinitis (4-year cumulative incidence: 30vs 10.7%) and asthma (24.1vs 10.5%) in the AIT group (n=987) than in the pharmacotherapy group (n=2012). Conclusion: Immunotherapy is associated with a significant reduction of pharmacotherapy in children. This is a marker of clinical control and could be associated with positive economic impact.
Published Version
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