Abstract
Cadmium ion (Cd2+) is a highly toxic heavy metal pollutant with long biological half-life and strong bioaccumulation, which may cause irreversible damage to human health even at low-dose intake. Sensitive and specific detection of ultra-trace Cd2+ is of great significance in food safety and environmental monitoring. In this work, a simple-to-use aptasensor to rapidly detect Cd2+ in various liquid media is developed based on a DNA aptamer modified gold interdigitated electrode (IDE). Capacitance at the solid-liquid interface is utilized to reflect the change caused by adsorbed Cd2+. With the microfluidic enrichment by AC electrothermal (ACET) effect, Cd2+ ions are sped up toward the IDE surface and captured by the probes instantaneously. Owing to the integration of target enrichment and capacitance detection, the sample-to-result time of this sensor is as short as 30 s. This aptasensor as a quantitative detector has a linear response range from 0.45 fM to 4.5 pM, with a limit of detection of 253.16 aM. The selectivity ratio reaches 2320: 1 against non-target metal ions. By detection of Cd2+ spiked in tap water and olive oil as well as natural residual Cd2+ in rice leaching solution, the sensor’s applicability and reliability in different practical liquid media are demonstrated.
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