Abstract
Lafaille-Magnan et al.1 reported that the association between odor identification deficits and cognition in older adults at increased risk of Alzheimer disease (AD) was driven by the presence of AD-related CSF biomarkers rather than the effects of age or other confounders. In addition, the findings were best explained by CSF tau rather than β-amyloid levels. These findings agree with postmortem observations that neurofibrillary tangles in the mesiotemporal lobe robustly predict olfactory deficits in the elderly.2 Dementia with Lewy bodies (DLB) is the second most common type of dementia; odor identification deficits in this hypodopaminergic disorder tend be more severe than in AD.3 However, tau pathology in DLB is substantially less severe compared to AD, including the mesiotemporal lobe.4
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