Reaction of Organometallic Compounds with Polyfluorinated Benzene Derivatives: Synthesis of 1-[3-(2,4-Difluorobenzoyl)-Phenyl]-Propan-1-One

Abstract

The abnormally high acidity of the aromatic proton placed between two fluorine atoms in the benzene ring renders the compounds with this substitution pattern incompatible with the conventional organometallic compounds in synthetic processes. The synthesis of 1-[3-(2,4-difluorobenzoyl)-phenyl]-propan-1-one via the Stille reaction is reported as a remedy.