Abstract
The reaction of nicotinic and isonicotinic acid hydrazides with o -formyl benzoic acid in ethanol led to the formation of the corresponding hydrazones. It was found that o -formyl benzoic acid reacted in aldehyde form with hydrazides to form hydrazones. When heated in acetic anhydride, the latter are smoothly cyclized into 3-acetoxyisoindoline-1-ones. Structure of the synthesized compounds was proved by 1H and 13C NMR spectroscopy data. Antiradical and antiviral activity of the synthesized hydrazones and 3-acetoxyisoindoline-1-ones was studied. A compound with a wide spectrum of virus-inhibiting action against strains of the A virus was identified.
Published Version
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