Re-defining the effect of exogenous lh activity (exLH) in follicular stimulation: an analysis of 10,280 cycles validating the importance of exLH in preventing a premature rise in progesterone (P)

Abstract

Elevated late follicular P levels prior to surge are associated with poor ART outcomes. The rises are commonly attributed to excessive endogenous or exogenous LH stimulation. While excessive LH effect may induce “premature luteinization,” inadequate exLH may also result in P accumulation due to inadequate stimulation of thecal conversion to androgens. This study evaluates exLH stimulation and follicular phase P levels sufficient to alter IVF cycle outcomes.