Abstract
Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide. To develop treatments that can stop or lessen the symptoms and severity of SARS-CoV-2 infection, it is critical to understand how the virus behaves inside human cells, and so far studies in this area remain scarce. A recent study investigated translatome and proteome host cell changes induced in vitro by SARS-CoV-2. Here, we use the publicly available proteomics data from this study to re-analyze the in vitro cellular consequences of SARS-CoV-2 infection by impact pathways analysis and network analysis. Notably, proteins linked to the inflammatory response, but also proteins related to chromosome segregation during mitosis, were found to be altered in response to viral infection. Upregulation of inflammatory response proteins is in line with the propagation of inflammatory reaction and lung injury that is observed in advanced stages of COVID-19 patients and which worsens with age.
Highlights
Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide [1]
After false discovery rate (FDR) correction, six pathways were found to be significantly impacted at 24 h post-infection, two pathways were found to be significantly impacted at 6 h post-infection, and no pathways were found to be significantly impacted at 2 h and 10 h post-infection (Figure 1A)
Www.aging-us.com six pathways were found to be significantly impacted at 24 h post-infection, and two at 6 h post-infection, the number of differentially expressed (DE) proteins in these pathways was low
Summary
Coronavirus disease 2019 (COVID-19), caused by an outbreak of the severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) in Wuhan, China, has led to an unprecedented health and economic crisis worldwide [1]. As of May 25th 2020, there are 5,304,772 confirmed cases and 342,029 confirmed deaths, with 216 countries affected (WHO, https://www.who.int, data accessed on May 25th 2020). These figures make COVID-19 the biggest health emergency of the 21st century. With neither an effective treatment nor vaccine available, the main controlling measure taken by nations has been social distancing followed by partial or total preventative lockdown. These control measures alone have led to the biggest global economic crisis of the 21st century
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