Abstract
To determine if inhibition of a rabbit aorta contracting substance (RCS) corresponds to inhibition of thromboxane synthelase human washed platelets were stimulated with thrombin. RCS formation was bioassayed on rabbit aorta strips in Tyrode solution containing selective blocking agents and thromboxane (TX)B 2 in the same probes by specific radioimmunoassay. Dazoxiben inhibited the formation of TXB 2 but not of RCS, whereas indomethacin inhibited both RCS and TX formation. The data indicate that the rabbit aorta cannot be used alone to predict inhibition of TX formation with specific TX synthetase inhibitors.
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