RBinds: A user-friendly server for RNA binding site prediction

Abstract

RNA performs various biological functions by interacting with other molecules. The knowledge of RNA binding sites is essential for the understanding of RNA-protein or RNA-ligand complex structures and their mechanisms. However, the RNA binding site prediction study requires tedious programming scripts and manual handling. One user-friendly bioinformatics tool for RNA binding site prediction has been missing. This limitation motivated us to develop the RBinds, a user-friendly web server, to predict the RNA binding site using a simple graphical user interface. Some advanced features implemented in RBinds are (1) transforming the RNA structure to a network automatically; (2) analyzing the structural network properties to predict binding site; (3) constructing one annotated force-directed network; (4) providing a visualization tool for users to scale and rotate the structure; (5) offering the related tools to predict or simulate RNA structures. RBinds web server is a reliable and user-friendly tool and facilitates the RNA binding site study without installing programs locally. RBinds is freely accessible at http://zhaoserver.com.cn/RBinds/RBinds.html.