Abstract
Experimental studies, when carried out under well controlled experimental conditions and planned to investigate specific endpoints, can provide reliable information on many aspects of the biological action of radiation. In particular, animal studies are suitable to help in determining the shapes of the dose-response relationships for tumour induction, and the influence of dose rate, and in understanding the species and strain dependence, as well as the effect of factors such as sex, age and hormonal status. All these variables can diversely influence the biological response to radiations of different qualities, and thus the RBEs. These aspects are examined and discussed in the paper, special attention being addressed to the tumour induction response of the haemolymphopoietic tissue and of epithelial tissues, such as liver and ovary, which have shown an appreciable degree of susceptibility to radiation carcinogenesis.
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