Abstract
The functional role and structure of skeletal muscle results in anisotropy in both material properties and imposed stresses, as well as waveguide effects. Dynamic elastography reconstruction methods for estimating muscle tissue viscoelastic properties that are rooted in assumptions of isotropy and bulk wave motion may produce inaccurate estimates. The superposition of axially-aligned orthotropy (transverse isotropy) in material properties and axially-aligned prestress conditions due to passive stretch or muscle activation makes it difficult to independently discern how much of the apparent anisotropy is due to the muscle material or the imposed stress field. Furthermore, this stress field may result in large strain conditions that require use of higher order terms in the stress-strain relationship. The significance of this confounding condition and strategies for decoupling material and stress-based anisotropy are investigated with a series of numerical finite element and experimental elastography studies using scanning laser Doppler vibrometry and magnetic resonance elastography. Shear and Rayleigh-Lamb wave motion is studied in a polymeric muscle phantom that is in the shape of a rectangular rod and has either isotropic or transversely isotropic material properties under zero stress conditions. [Funding support: NIH AR071162]
Published Version
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