Abstract
Rationale for Manufacturing of Cut-Pressed Granules from Herbal Raw Material Rich in Essential Oil: An Example of Chamomile Flowers and Sweet Flag Rhizome
Highlights
Providing access to the novel safe and effective high-quality medicinal products is the ultimate aim of the pharmaceutical industry
Herbal powders often demonstrate poor flow properties, which often hinder exact dosing on high-performance manufacturing lines. This negative factor affects most of the cut and powdered dosage forms, including herbal drugs released in tea bags; it is usually mitigated by special treatment of herbal raw material.[2,3,4]
Commercial batches of powdered chamomile flowers (Matricaria recutita L., flos; corresponds to the requirements of the State Pharmacopoeia9) and powdered sweet flag rhizome (Acorus calamus L., rhizome; corresponds to the requirements of the State Pharmacopoeia12) were used in the study
Summary
Providing access to the novel safe and effective high-quality medicinal products is the ultimate aim of the pharmaceutical industry. Herbal powders often demonstrate poor flow properties, which often hinder exact dosing on high-performance manufacturing lines This negative factor affects most of the cut and powdered dosage forms, including herbal drugs released in tea bags; it is usually mitigated by special treatment of herbal raw material.[2,3,4]. A novel, unique dosage form – cut-pressed granules (CPG) – was developed in order to improve manufacturing characteristics and, quality of herbal drug products released in tea bags. The study showed that the granulation process, promoted stability of the dosage form: during long-term storage the content of essential oil in all of the assessed cut-pressed granules was equivalent or higher than in corresponding herbal raw material.
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