Anti-&amp;lt;i&amp;gt;Helicobacter&amp;lt;/i&amp;gt; Activity of Certain Food Plant Extracts and Juices and Their Composition &amp;lt;i&amp;gt;in Vitro&amp;lt;/i&amp;gt;

Vizma Nikolajeva,Anna Babarikina,Dmitry Babarykin

doi:10.4236/fns.2011.28118

Abstract

Plant material screening was performed to study anti-Helicobacter pylori activity in vitro using an agar diffusion method on Columbia blood agar. 33 substances, juices and plant extracts and 35 of their combinations were tested. Quince (Cydonia oblonga) juice demonstrated the strongest anti-H. pylori activity followed by cranberry juice. Con-centrated apple juice, plum, red currant, black chokeberry, raspberry and bilberry juice also showed significant activity. Green tea and apple pomace extract as well as sweet flag rhizome, ginger and wild bergamot extract, cherry syrup, red beet juice and whey did not exhibit anti-Helicobacter activity. Quince juice in combination with bilberry, black chokeberry, red currant juice, green tea, sweet flag rhizome or apple pomace extract as well as cranberry juice in combination with sweet flag rhizome extract demonstrated a synergistic effect on inhibition of H. pylori. The obtained results offer new perspectives for development of functional anti-Helicobacter food product(s) for dietary management of H. pylori infection. The essential components of these products could be the most active juices and extracts like quince and cranberry juice supplemented with a corresponding synergist. Further studies are required to investigate the mechanism of antibacterial action of plant products and their efficacy in vivo.

Highlights

Helicobacter pylori is a common bacterium and unique among pathogens
Its activity exceeded the activity of cranberry juice (Table 1) and it was less dependent on dilution than cranberry juice
The presumption was stated that the possible synergistic effects of different dietary combinations of these extracts may be a factor in the possible protection afforded by the traditional Iranian diet against H. pylori infection [20]

Summary

Introduction

Helicobacter pylori is a common bacterium and unique among pathogens. It can persist in the acidic environment of the human stomach. Urease is required for survival at pH 4.0 and below, whereas at higher acidic pH, mechanisms independent of urease are protective [1]. Expression of approximately 7% of the H. pylori genome is reproducibly altered by a shift to low pH [2]. A large number of reports have been produced on H. pylori and its pathogenetic potential.

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Conclusion