Abstract
A new fabrication of [Cu3(μ2-H2O)(PHB)(H2O)]·(DMF)3(H2O)6 (GDMU-2) was synthesized and used as a drug vehicle of 5-Fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the GDMU-2 was around 53.7wt% per gram of dehydrated GDMU-2. Cargo release behavior and material degradation profile were also investigated under different pH. 5-FU is released in a highly controlled and progressive manner with 100% of the drug release after 97h at acidic condition and with 83% after 132h at PBS. In vitro cytotoxicity assays indicated that the GDMU-2 possesses no obvious cytotoxicity. The result from this work provides a new avenue for MOF to be used as potential drug delivery.
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